Are you ready for some football? NFL Week 1 begins in four weeks with the Super Bowl champion Tampa Bay Bucs kicking off the season on Thursday Night Football against the Dallas Cowboys. Oddsmakers posted lines for NFL betting action and the big favorites heading into Week 1 include the Tampa Bay Bucs, San Francisco 49ers, Los Angeles Rams, and Buffalo Bills. All four teams are favorites by a touchdown or more.

Matthew Stafford LA Rams Sean McVay NFL Week 1 lines
LA Rams head coach Sean McVay chats with new quarterback Matthew Stafford during training camp. (Image: Gary A. Vasquez/USA Today Sports)

Once again, the defending Super Bowl champion gets the honor of opening the season with an appearance on Thursday Night Football. If you’re a Brady hater, then get used to seeing his mug a lot this season because the Bucs appear in multiple national broadcasts.

The Kansas City Chiefs are the current favorite to win the Super Bowl at +500 odds, according to a recent update by the Westgate SuperBook in Las Vegas. Tom Brady and the Bucs are right behind them at +600 odds to win back-to-back Super Bowls. Josh Allen and the Buffalo Bills are the third-highest team on the NFL futures board. The Bills are +1000 odds to finally win a championship.

Now that Aaron Rodgers will suit up for the Green Bay Packers this season, the Packers are +1300 odds to win Super Bowl 56. If you “follow the money”, the public thinks that the Packers and Bucs will meet in the NFC Championship Game to play the winner of the Chiefs and Bills in the AFC title game.

NFL Week 1 Lines and Totals
Week 1
Line Total
TNF: Dallas Cowboys at Tampa Bay Bucs TB -7 52
Jacksonville Jaguars at Houston Texans JAX -3 45.5
Pittsburgh Steelers at Buffalo Bills BUF -7 50.5
New York Jets at Carolina Panthers CAR -4.5 43
Arizona Cardinals at Tennessee Titans TN -3 51.5
LA Chargers at Washington Football Team LAC -1.5 44.5
Minnesota Vikings at Cincinnati Bengals MIN -3 48.5
San Francisco 49ers at Detroit Lions SF -7.5 46
Philadelphia Eagles at Atlanta Falcons ATL -3.5 48
Seattle Seahawks at Indianapolis Colts SEA -3 46.5
Denver Broncos at NY Giants DEN -1 42.5
Green Bay Packers at New Orleans Saints GB -3 49.5
Cleveland Browns at Kansas City Chiefs KC -6 53.5
Miami Dolphins at New England Patriots NE -2.5 45
SNF: Chicago Bears at LA Rams LAR -7 45
MNF: Baltimore Ravens at Las Vegas Raiders BAL -4.5 51

** All lines by Westgate SuperBook

Quick glance: Jets/Panthers, Rams/Bears, Ravens/Raiders

The Dallas Cowboys drew a tough opponent to kick off the season against Brady and the Bucs in Week 1. Dak Prescott is attempting to come back from a fractured ankle, but he’s been hampered with other injuries during the preseason. The Los Angeles Rams and the Chicago Bears clash in the first Sunday Night Football broadcast this season. With Matthew Stafford at the helm, the Rams are favorites by -7 under the bright lights of SoFi Stadium in LA.

Lamar Jackson and the Baltimore Ravens hit the road to play the Las Vegas Raiders on Monday Night Football in Sin City. The Raiders are a +4.5 home dog in the first MNF broadcast of the season. The New York Jets traded Sam Darnold to the Carolina Panthers to make room for the #2 pick in the draft, Zach Wilson. Darnold gets a chance to prove to his old team that they made a crucial mistake with a big game in Week 1. The LOLJets are a +4.5 underdog in Rob Saleh’s coaching debut.

Baker Mayfield and Pat Mahomes throw down in the first week of the season when the Cleveland Browns visit the Kansas City Chiefs. Mahomes and Kansas City are -6 favorites, and bookies think this will be a high-scoring affair with a 53.5 over/under total.

Rodgers and the Packers head down to the Big Easy to play the New Orleans Saints. It’s the first Saints game after Drew Brees retired, but the Saints are +3 home dogs at the Superdome. Trevor Lawrence, the #1 pick in the 2021 NFL Draft, makes his pro debut against the Houston Texans. With the future of Deshaun Watson in doubt, the Texans are +3 home dogs against Lawrence and the Jags.