Oddsmakers posted opening betting lines for Week 4 of the NFL season, which is anchored by a Sunday Night Football battle between the defending champion Tampa Bay Buccaneers and the New England Patriots. The game marks the first time quarterback Tom Brady returns to Foxboro to take on his former head coach and ex-team.

Tom Brady Tampa Bay Bucs Week 4 NFL Opening lines Buffalo Bills New England Patriots
Samson Ebukam from the Los Angeles Rams sacks Tom Brady of the Tampa Bay Bucs in Week 3 at SoFi Stadium in LA. (Image: Jason Behnken/AP)

The Bucs don’t have time to lament over their 34-24 loss against the LA Rams in Week 3 with a circus-like atmosphere awaiting them in New England.

The Buffalo Bills enter Week 4 as the biggest favorite on the board when they opened as a -17.5 favorite over the Houston Texans. The Bills are currently -17 against rookie quarterback Davis Mills, who lost his starting debut on Thursday Night Football against the Carolina Panthers.

NFL Week 4 Opening Lines
Jacksonville Jaguars at Cincinnati Bengals Cin -7.5 45.5
Washington Football Team at Atlanta Falcons PK 48.5
Houston Texans at Buffalo Bills BUF -17 48
Detroit Lions at Chicago Bears CHI -3 43.5
Carolina Panthers at Dallas Cowboys DAL -4.5 50
Indianapolis Colts at Miami Dolphins MIA -2 43.5
Cleveland Browns at Minnesota Vikings CLE -1 53
New York Giants at New Orleans Saints NO -8 43.5
Tennessee Titans at New York Jets TN – 7.5 46
Kansas City Chiefs at Philadelphia Eagles KC – 5.5 55
Arizona Cardinals at LA Rams LAR -6 54.5
Seattle Seahawks at San Francisco 49ers SF – 2.5 52.5
Baltimore Ravens at Denver Broncos DEN -1.5 44.5
Pittsburgh Steelers at Green Bay Packers GB -7 45.5
Tampa Bay Buccaneers at New England Patriots
TB -6 48.5
Las Vegas Raiders at Los Angeles Chargers LAC -3

According to the Westgate SuperBook in Las Vegas, the Week 4 opening lines featured a pair of pick’em games. The Minnesota Vikings host the Cleveland Browns, which opened as pick’em on Sunday evening. As of Monday morning, the Vikings are currently a +1 home dog. The Atlanta Falcons host the Washington Football Team in Week 4 in the other pick’em game.

Week 4 totals

In Week 4, 43.5 is the low-water mark for over/under totals. Oddsmakers anticipate low-scoring games with the Detroit Lions at Chicago Bears (43.5 o/u), Indianapolis Colts at Miami Dolphins (43.5 o/u), and the New York Giants at the New Orleans Saints (43.5 o/u).

If you love to pound the over, then keep an eye on the Kansas City Chiefs at Philadelphia Eagles matchup that currently has a total at 55 o/u. The Arizona Cardinals head to Hollywood to play the LA Rams in a battle of undefeated teams. The Cards/Rams showdown total opened at 53, but the total is currently at 54 and rising. Also, keep an eye on the total for Monday Night Football. The LA Chargers host the Las Vegas Raiders and bookies think that will also be a shootout, with a total of 52.5 o/u.

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